This substance ranges from B to C depending on concentration/usage. 11.1. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol. US NIOSH Target Organs & Routes of Entry SUBJECT: Reassessment of Tolerance Exemptions for Ethylene Glycol, Diethylene Glycol, Diethylene Glycol Monomethyl Ether, Diethylene Glycol Monoethyl Ether, and Diethylene Glycol Monobutyl Ether FROM: Kit Farwell, D.V.M. Occupational Exposure to Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate. Clipboard, Search History, and several other advanced features are temporarily unavailable. EGBE is manufactured by adding n-butyl alcohol and ethylene oxide. Chronic exposure in humans is associated with neurological and blood effects, such as nausea, tremor, and anemia. Nausea and … Transient non-cardiogenic pulmonary edema following massive ingestion of ethylene glycol butyl ether. Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. In both the ethylene and diethylene glycol series, the relative rate of absorption declined from methyl to ethyl to butyl ether derivatives. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. 111-76-2], considering butoxyacetic acid in urine to characterise the internal exposure. 1984 Aug;57:75-84. doi: 10.1289/ehp.845775. Reregistration Branch 1 Health Effects … NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Ethylene Glycol Monobutyl Ether (Laboratory) Revision Date 15-Dec-2015 Engineering … Google Scholar Read More. The level of exposure depends upon the dose, duration, and work being done. NLM DIETHYLEN Glycol M-ETHYL ETHER Liquid. Skin Contact Rinse with clear water  |  some . OBJECTIVES To investigate the effects of ethylene glycol monomethyl ether (EGME) on haematology and reproduction in exposed workers. During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. Stability No data submitted 3.2. 1984 Aug;57:233-9. doi: 10.1289/ehp.8457233. It attacks some forms of plastics, rubber and coatings. ethylene glycol was prepared by the Institute of Terrestrial Ecology, United Kingdom, based on the report Environmental hazard assessment: Ethylene glycol (Nielsen et al., 1993). Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. ETHYLENE GLYCOL ETHERS PANEL TO REMOVE ETHYLENE GLYCOL MONOBUTYL ETHER FROM THE TOXICS RELEASE INVENTORY UNDER SECTION 313 OF THE EMERGENCY PLANNING AND COMMUNITY RIGHT-TO-KNOW ACT OF 1986 Jonathon Busch Director, Ethylene Glycol … Aspects of biological monitoring of exposure to glycol ethers. 2-BE … Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. FIRST AID MEASURES First aid measures Eye contact Rinse … ETHYLENE OXIDE Causes reproductive effects . -. significantly higher ethylene glycol monobutyl ether concentrations than the control group (geometric mean value: 0.14vs. It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. 2-Butoxyethanol is a clear colorless liquid that smells like ether. 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. 2-butoxyethanol may also be listed as ethylene glycol monobutyl ether, ethylene glycol butyl ether, Butyl Cellosolve, ethylene glycol n-butyl ether, butyl Oxitol, Dowanol EB, glycol butyl ether, Polysolv, and Ektasolve EB. … DIETHYLEN Glycol M-ETHYL ETHER Liquid. Archives of Toxicology, 82(2), 125-136. NIOSH Criteria for a Recommended Standard. 1. 1994;66(4):249-54. doi: 10.1007/BF00454363. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Tyl RW, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC. Acute toxicity: Oral: Harmful if swallowed. Ethylene Glycol Monobutyl Ether; Community Right-To-Know Toxic Chemical Release Reporting, 60818-60825 [2015-25674] In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Ethylene Glycol Ethers Group - information sheet - Canada.ca Int J Toxicol. Read More. Arch Toxicol. Respiratory Effects: Inhaled ethylene glycol can irritate the respiratory tract. It is also used in some ink and spot remover compounds. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol… 2-Butoxyethanol acetate is a colorless liquid with a fruity odor. Exposure to 60 ppm aerosolized ethylene glycol caused very noticeable irritation. 1984 Aug;57:47-68. doi: 10.1289/ehp.845747. O-butyl ethylene glycol butyl glycol EGBE ethylene glycol n-butyl ether glycol butyl ether monobutyl glycol ether 3-oxa-1-hepatanol Chemical name (CAS) 2-butoxyethanol CAS number 111-76-2 Since the MAK documentation from 1983 and 1986 (“2-Butoxyethanol”, Volume 6,  |  Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. Symptoms/effects after skin contact : Harmful in contact with skin. Environ Health Perspect. A U.S. … (USCG, 1999) Ethylene … Find Lowest Prices. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. tration. Studies on ethylene glycol alkyl ethers and related compounds … 4 Fukushima Medical University. 4. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. Diethylene glycol ethers were absorbed more slowly than the corresponding ethylene glycol ethers. Starek, A., Szymczak, W. and Zapór, L. (2008) Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats. Ingestion or skin contact causes headache, nausea, vomiting, dizziness. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm. Information on toxicological effects . -, Nature. USA.gov. DIPROPYLENE GLYCOL BUTYL ETHER can be found in 39 products. I. NIOSH Pocket Guide to ... in this product - not the product itself - compared to other product formulations. The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Most important symptoms and effects, both acute and delayed Symptoms/effects after inhalation : Harmful if inhaled. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. 2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484 Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Studies on EGM using hamsters or guinea pigs revealed the occurrence of testicular atrophy similar to that observed in mice. Precautions. Fast, free, expert help 24×7×365 1‑800‑222‑1222. DEG is a widely used solvent. 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, ... if they do, what the type and severity of these health effects … It is miscible in water, alcohol, ether, acetone, and ethylene glycol… 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol… Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. J Occup Health. Flammable and/or toxic … 2-Butoxyethanol autoprotection is due to resiliance of newly formed erythrocytes to hemolysis. Pubmed Abstract In evaluating the hazard that this chemical … Diethylene Glycol Poisoning -, Sangyo Igaku. In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Int Arch Occup Environ Health. People who swallowed large amounts of cleaning agents containing 2-butoxyethanol have shown breathing problems, low blood … Epub 2017 Jun 26. Initial adverse health effects caused by ethylene glycol intoxication include central nervous system depression, intoxication, euphoria, stupor, and respiratory depression. On the other hand, ethylene glycol, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monoacetate or ethylene glycol diacetate showed no such an effect. Another group of 121 lamination workers with indirect exposure to EGME was recruited as the control group. Print Share on: Evidence. 4.3. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. by Alicia Minns, MD. HHS It is miscible in water, alcohol, ether, acetone, and ethylene glycol. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. 4 Fukushima Medical University. CAS-Number. Vapors irritate eyes and nose. 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, butyl Oxitol, glycol butyl ether… Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects… 2-Methoxyethanol (McGregor et al., 1983), ethylene glycol monobutyl ether (Tyler, 1982), dlethylene glycol monobutyl ether (Thompson et al., 1984), dlethylene glycol dimethyl ether (McGregor et al., 1983), propylene glycol methyl ether {Mendrala, 1983c), and dlpropylene glycol methyl ether (Mendrala, 1983b) were negative 1n the cell culture test for unscheduled DNA synthesis. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. EPA/635/R-08/006F. 1983 May;68(3):405-14 Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. 57, pp. 1979 Jan;21(1):29-35 I.A. This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. METHODS 53 Impregnation workers from two factories that make copper clad laminate with EGME as a solvent were recruited as the exposed group. 1. 3 Independent Consultant. 2-Butoxyethanol (2-BE), also known as ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour. 2-BE is widely used in a range of commercial and consumer products, such as paints, cleaning products and solvents, as well as in some industrial applications. Consult a physician. 1974 Feb;27(2):342-54 Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism, disposition, and subchronic inhalation toxicity studies. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. The ratings reflect potential health … 1988 Oct;43(1-3):5-21. doi: 10.1016/0378-4274(88)90017-3. For this reason, some items on this page will be unavailable. ETHYLENE OXIDE Causes reproductive effects . No harmful effects were seen on their lungs or hearts. Chemical Name. This database provides human health benchmarks for pesticides that may be present in drinking water. ICSC Routes of Exposure and Symptoms. The main systemic adverse effects of 2-butoxyethanol are on the haematopoietic system (haemolytic effects), followed by possible teratogenic and testicular effects. Ethylene glycol monobutyl ether has also been tested for teratogenldty … ICSC Long-Term Exposure. This can cause anemia. This assessment summarizes available information on It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. Cohen, R. (1984) Reversible subacute ethylene glycol monomethyl ether toxicity associated with microfilm production, a … " DISCLAIMER: The ILO does not take responsibility for content presented on this web portal that is presented in any language other than English, which is the language used for the initial production and peer-review of original content. (ethylene glycol monobutyl ether) [CAS No. 1984 Aug;57:165-75. doi: 10.1289/ehp.8457165. The acute and subehronic toxicity of EGEE, EGPE and EGBE was reviewed by C. C. Conaway (Texaco, Substance name : Glycol Ether EB CAS-No. -, Toxicol Appl Pharmacol. Where is it found and how is it used? 1987 Nov;91(2):222-34. Histopathological effects consisted of excessive extramedullary splenic hematopoiesis, renal tubular degeneration, hemosiderin deposition in the spleen and kidney and accumulation in Kupffer cells, and … 1995;69(8):526-32. doi: 10.1007/s002040050207. 1977 May 26;267(5609):335 Summary: 2-Butoxyethanol is a clear colorless liquid that smells like ether. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE For Synthesis Safety Data Sheet www.lobachemie.com 03/06/2016 3/8 4.2. Ethylene Glycol Monoethyl Ether (110-80-5) LD50 oral rat 1746 mg/kg LD50 dermal rabbit … : 111-76-2 Formula : C6H14O2 Synonyms : 2-butoxyethanol / BGE / butyl cellosolve / butyl OXITOL / butylglycol / butylglycol ether / EGBE / ethanol, 2-butoxy- / ethyleenglycolmonobutylether / ethylene glycol monobutyl ether / glycolmonobutylether / monobutyl ether … Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. Environ Health Perspect. It compiles information from several government agencies and organizations. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant ... 2 Japan Industrial Safety and Health Association. Toxicol Appl Pharmacol. Opinion on Ethylene glycol monobutyl ether _____ 7 3.1.9. 3 Independent Consultant. Animal studies have reported reproductive and developmental risks from inhalation … Effects observed in humans included nasal and … Health Hazard Assessments for Noncarcinogenic Effects . The ether being relatively unreactive. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, ... 2 Japan Industrial Safety and Health Association. Environ Health Perspect. COVID-19 is an emerging, rapidly evolving situation. J Occup Health. Substance Name — Ethylene glycol monobutyl ether (EGBE) CASRN — 111-76-2 Last Revised — 3/31/2010 . Epub 2017 Jun 26. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. Symptoms may include tiredness, … The RfD is an estimate (with uncertainty … Throat and upper respiratory irritation were the most common complaints following prolonged experimental exposures in humans (4 weeks at concentrations of 1-25 ppm). Precautions. Cincinnati, OH, US Department of Health and Human Services, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 1990. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health… -, Toxicol Appl Pharmacol. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2006;25 Suppl 2:121-38. doi: 10.1080/10915810600964642. effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether ... toxicity data for EGBE and concluded that it can reasonably be anticipated to cause serious or irreversible chronic health effects in humans, specifically, liver toxicity and concerns for hematological effects. It is also known as ethylene glycol monobutyl ether acetate, butoxyethyl acetate, butyl glycol acetate, ethylene glycol butyl ether acetate, and acetic acid 2-butoxyethyl ester. It is an ether-ester derivative. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. (1993) Technical report on toxicity studies of ethylene glycol ethers 2-methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3F1 mice. NIH 2-BE itself is not commercially produced in Canada. Final report on the safety assessment of Triethylene Glycol and PEG-4. Would you like email updates of new search results? Health Effects Division (7509C) Pauline Wagner, Chief Inert Ingredient Assessment Branch (IIAB) Registration Division (7505C) BACKGROUND Attached is the science assessment for one exemption from the requirement of a tolerance for ethylene glycol monobutyl ether (EGBE). Inhalation: Toxic ifinhaled. 4. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. 1970 Jan;27(1):1-18 Information available on … 2-Butoxyethanol was classified in Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate … Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. 1992;18(4):250-1. doi: 10.1007/BF01709843. Note: Javascript is disabled or is not supported by your browser. Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. Find Lowest Prices. some . Br J Ind Med. Reference Dose (RfD) for Chronic Oral Exposure . According to Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. Miller RR, Hermann EA, Young JT, Landry TD, Calhoun LL. Ethylene Glycol Monobutyl Ether 111-76-2 <25 * *The exact percentage (concentration) of composition has been withheld as a trade secret. 0.03ppm; P=0.017). Please enable it to take advantage of the complete set of features! ICSC Short-Term Exposure. Abbreviations for 2-butoxyethanol include EGBE and BE [1]. In the first study, a group of two men and six rats were exposed simultaneously for 4 hours to an EGBE concentration of 113 ppm in a 1,250 cubic ft room. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. Environmental Health Perspectives Vol. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). Workers may be harmed from exposure to 2-butoxyethanol. Environ Health Perspect. It is liable to form peroxides on exposure to air and light. Likely routes of exposure : Inhalation; Skin and eye contact . It can harm the eyes, skin, kidneys, and blood. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, 2-Butoxyethanol and 2-Butoxyethanol Acetate, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information.  |  Effects of short-term exposure The substance is irritating to the eyes, skin and respiratory tract. Toxicol Lett. Office of Pesticide Programs Pesticide Chemical Search. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. This site needs JavaScript to work properly. NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC) ... compared to other product formulations. FIRST AID MEASURES First aid measures Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. In humans, 100 ppm (69 mg/kg bw/day) resulted in ocular and respiratory Irritation, altered taste and nausea (Carpenter et al., 1956). A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects… ethylene glycol ethers (but not propylene glycol ethers) can damage red blood cells or damage the bone marrow, where blood cells are formed. The substance may cause effects on the central nervous system, blood, kidneys and liver. In this document, NIOSH recommends occupational exposure limits for ethylene glycol monobutyl ether (EGBE) and its acetate, ethylene glycol monobutyl ether acetate (EGBEA). Where is it found and how is it used? REACH regulation aims to improve the protection of human health and the environment from the risks that can be ... new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects ... 2-butoxyethanol ethylene glycol monobutyl ether butyl cellosolve . 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Some chromatograms showed that subjects were co-exposed to m-xylene, ethylene glycol monomethyl ether, and ethylene glycol monoethyl ether acetate. B to C depending on concentration/usage associated with neurological and blood humans included nasal and … it can harm eyes. 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